These tools are designed for use at the point-of-care. The evidence is filtered and pre-appraised to only include studies of higher quality, and is updated frequently. Levels of evidence are often included.
Lister Hill Library
For busy clinicians, searching PubMed for evidence to answer all the clinical questions encountered in a day would be a daunting task!
The 6S Model hierarchy was developed to guide decision-making based on pre-appraised literature. The clinical tools in the box on the left can be used to answer the most common questions using pre-appraised evidence. Start at the top and work down.
Use PubMed Clinical Queries to quickly locate articles limited to specific clinical research areas. (For comprehensive searches, search PubMed directly.)
1. Click on Clinical Queries, then type your search into the search box as shown below.
2. Choose the clinical study category, and Narrow/Broad. If desired, use the drop down to narrow the Medical Genetics search. The results for the Study Category, Systematic Reviews on the search topic, and results limited to articles about medical genetics will be displayed too.
An evidence pyramid is a visual representation of the strength of evidence. When possible, clinical decisions are based on studies at the top of the pyramid.
The level of evidence is based on the research design used to conduct the study. The most scientific, rigorous designs are randomized controlled trials, systematic reviews, and meta-analysis. These designs reduce opportunities for bias and confounders.
Use the "Article Types" filters on the left sidebar in PubMed to limit your search to Meta-Analysis, Systematic Reviews or Randomized Control Trials. "Practice Guidelines" is also available. If you choose more than one, the limiters will be searched with OR.